2023 World Conference on Lung Cancer (Posters)-EP11.03. Sarcopenia Is a Poor Predictive Prognostic Factor for Non Small Cell Lung Cancer Patients Who Were Treated with Immune Check Point Inhibitors

EP11.03. Sarcopenia Is a Poor Predictive Prognostic Factor for Non Small Cell Lung Cancer Patients Who Were Treated with Immune Check Point Inhibitors - PDF(Abstract)

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This study aimed to analyze the effect of sarcopenia, a condition characterized by muscle loss, on the treatment of non-small cell lung cancer (NSCLC) patients with immune checkpoint inhibitors (ICI). The researchers prospectively analyzed 80 NSCLC patients who received ICI as a first-line treatment at Korea University Guro Hospital. Sarcopenia was diagnosed using a dual energy X-ray absorptiometry test.<br /><br />Of the 80 patients, 70 were classified as having sarcopenia and 10 as normal. There were no baseline differences in characteristics between the two groups. Analysis showed a statistically significant increase in inflammatory cytokines (IL-6, IL-8, IL-10) in the sarcopenia patient group. There was also an increase in T regulatory (Treg) cells and exhausted T-cells in the sarcopenia patient group. <br /><br />The researchers further analyzed the progression-free survival (PFS) using the Kaplan-Meier method and Cox proportional hazards model. The sarcopenia patient group showed a poor trend in PFS, although it was not statistically significant.<br /><br />The study findings suggest that sarcopenia causes abnormal inflammation and increases Treg cells and exhausted T-cells, which are associated with a poorer prognosis. Therefore, sarcopenia is identified as a poor predictive prognostic factor for ICI treatment in NSCLC patients.<br /><br />In conclusion, this study highlights the importance of considering sarcopenia as a factor in the treatment of NSCLC patients with ICI. This finding may have implications for the personalized management of NSCLC patients, as targeting sarcopenia and its associated immune alterations may help improve treatment outcomes.

Asset Subtitle

Sung Yong Lee

Meta Tag

Speaker Sung Yong Lee

Topic Metastatic NSCLC: Immunotherapy - Retrospective

Keywords

sarcopenia

muscle loss

non-small cell lung cancer

NSCLC

immune checkpoint inhibitors

inflammatory cytokines

T regulatory cells

exhausted T-cells

progression-free survival

prognostic factor