2023 World Conference on Lung Cancer (Posters)-EP12.01. The Optimal Intervention Timing of Aumolertinib Combined with HFSRT for EGFR Mutated NSCLC Patients with Multiple Brain Metastasess

EP12.01. The Optimal Intervention Timing of Aumolertinib Combined with HFSRT for EGFR Mutated NSCLC Patients with Multiple Brain Metastasess - PDF(Slides)

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Pdf Summary

A study aimed to evaluate the optimal timing of hypofractionated stereotactic radiotherapy (HSRT) for EGFR mutated NSCLC patients with multiple brain metastases. The study design involved performing large segmentation stereotactic radiotherapy on intracranial metastases using CT and MRI dual localization and fusion localization images. The objective outcomes assessed were intracranial progression-free survival (iPFS) and overall survival (OS). Secondary endpoints included objective response rate (ORR), disease control rate (DCR), safety, and quality of life of patients. The study compared an experimental group that received HSRT followed by targeted therapy with a control group that received targeted therapy first and radiotherapy upon progression of intracranial metastases. Patient selection criteria included histologically confirmed EGFR-mutant non-small cell lung cancer, Karnofsky Performance Status (KPS) score of 0-2, and the presence of 3-10 metastatic lesions without leptomeningeal metastases. The patients were followed up for a period of 2 to 5 years. The study is ongoing and is being sponsored by the Chinese Society of Clinical Oncology Foundation. The data from the study cannot be used for any commercial activity until the 2023 WCLC conference begins.

Asset Subtitle

Qian Shao

Meta Tag

Speaker Qian Shao

Topic Metastatic NSCLC: Targeted Therapy - EGFR/HER2

Keywords

hypofractionated stereotactic radiotherapy

EGFR mutated NSCLC

brain metastases

large segmentation stereotactic radiotherapy

CT and MRI dual localization

fusion localization images

intracranial progression-free survival

overall survival

objective response rate

disease control rate