2023 World Conference on Lung Cancer (Posters)-EP12.01. Validation of the ALK-Brain Prognostic Index (ALK-BPI) Model in Patients with ALK-rearranged Non-small Cell Lung Cancer and Brain Metastases

EP12.01. Validation of the ALK-Brain Prognostic Index (ALK-BPI) Model in Patients with ALK-rearranged Non-small Cell Lung Cancer and Brain Metastases - PDF(Slides)

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This study aimed to validate the ALK-Brain Prognostic Index (ALK-BPI) model, which was proposed for patients with ALK-positive non-small cell lung cancer (NSCLC) and brain metastases, using an external clinical cohort. The study included 94 patients from Heidelberg University Hospital who were treated with ALK inhibitors, and these patients were merged with the original Swedish discovery cohort of 44 patients from Karolinska University Hospital. The baseline demographics and characteristics of both cohorts were analyzed.<br /><br />Various statistical analyses were performed to determine prognostic variables associated with overall survival (OS) and evaluate the performance of the ALK-BPI model, as well as other prognostic scores. The ALK-BPI variables significantly influenced OS in both cohorts. The ALK-BPI model showed a consistent significant difference in median OS between the good and poor risk groups in both cohorts.<br /><br />The study concluded that the ALK-BPI model is a practical and novel prognostic tool for TKI-treated ALK NSCLC patients with brain metastases. It can be used to refine patient stratification in daily clinical practice. The validation study, which included patients from two large academic centers, confirms the utility of the ALK-BPI model for guiding treatment decisions and providing prognostic information for this patient population.

Asset Subtitle

Georgios Tsakonas

Meta Tag

Speaker Georgios Tsakonas

Topic Metastatic NSCLC: Targeted Therapy - EGFR/HER2

Keywords

ALK-Brain Prognostic Index

ALK-positive non-small cell lung cancer

brain metastases

ALk inhibitors

Heidelberg University Hospital

Karolinska University Hospital

prognostic variables

overall survival

prognostic scores

patient stratification