2023 World Conference on Lung Cancer (Posters)-EP13.04. Outcomes of Limited-Stage Extrapulmonary Small Cell Carcinoma and Small Cell Lung Cancer

EP13.04. Outcomes of Limited-Stage Extrapulmonary Small Cell Carcinoma and Small Cell Lung Cancer - PDF(Abstract)

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This document is a summary of a presentation at the WCLC 2023 conference titled "Outcomes of Limited-Stage Extrapulmonary Small Cell Carcinoma and Small Cell Lung Cancer." The study aimed to review the clinical features, treatment, and outcomes of patients with limited-stage small cell lung cancer (SCLC) and extrapulmonary small cell carcinoma (EPSCC).<br /><br />The study included 94 patients, 82 with limited-stage SCLC and 12 with limited-stage EPSCC. The primary sites for EPSCC included bladder, gallbladder, prostate, and breast. All SCLC patients had a history of smoking, while only 59% of EPSCC patients were smokers.<br /><br />The majority of SCLC patients received definitive chemoradiotherapy, while only one EPSCC patient received this treatment. Half of the EPSCC patients underwent surgery with adjuvant therapy, compared to only 7% of SCLC patients.<br /><br />The median overall survival (OS) was 25.8 months for SCLC patients and 16.2 months for EPSCC patients. The median recurrence-free survival (RFS) was 15.9 months for SCLC patients and 6.2 months for EPSCC patients.<br /><br />The authors concluded that the survival outcomes of patients with limited-stage EPSCC may differ depending on the origin of the cancer. They suggested that multi-modal therapy involving local therapy and platinum-based chemotherapy could optimize outcomes for EPSCC patients. However, the choice of local therapy may depend on the origin of the extrapulmonary cancer.<br /><br />The authors emphasized the need for future research to develop a standard approach to the treatment of limited-stage EPSCC.<br /><br />Keywords for the study include extrapulmonary small cell carcinoma, small cell lung cancer, and survival.

Asset Subtitle

Daniel Liem

Meta Tag

Speaker Daniel Liem

Topic SCLC & Neuroendocrine Tumors: LS-SCLC

Keywords

extrapulmonary small cell carcinoma

small cell lung cancer

clinical features

treatment

outcomes

limited-stage

patients

chemoradiotherapy

overall survival

recurrence-free survival