2023 World Conference on Lung Cancer (Posters)-EP14.01. Does Delaying Surgery Following Induction Chemotherapy Compromise Survival in Patients with Malignant Pleural Mesothelioma?

EP14.01. Does Delaying Surgery Following Induction Chemotherapy Compromise Survival in Patients with Malignant Pleural Mesothelioma? - PDF(Slides)

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The study aims to investigate whether delaying surgical resection following induction chemotherapy compromises survival outcomes in patients with malignant pleural mesothelioma (MPM), a rare disease associated with asbestos exposure. The researchers analyzed data from the National Cancer Database from 2004 to 2017. The results show that delaying surgery does not compromise cancer-related outcomes and may allow patients to recover from the toxicity of induction treatment before undergoing a radical operation. <br /><br />The study also found that higher comorbidity scores were associated with worse outcomes, but the timing of surgery did not have a significant association with increased mortality. The Cox proportional hazards modeling showed that only higher comorbidity scores were associated with worse outcomes. There was no difference in 5-year survival between immediate surgery and delayed surgery. <br /><br />The study suggests that future research should focus on new chemotherapeutic agents, patient condition, and disease progression prior to surgical interventions. It also highlights the need to determine the optimal sequence and timing of MPM treatment, including the role of adjuvant treatment. <br /><br />In summary, delaying surgery following induction chemotherapy in patients with MPM does not compromise survival outcomes. This may allow patients to recover from the toxic effects of induction treatment and be optimized before undergoing a radical operation. Further research is needed on novel chemotherapeutic agents, patient condition, and adjuvant treatment to determine the best treatment approach for MPM.

Asset Subtitle

Lye-Yeng Wong

Meta Tag

Speaker Lye-Yeng Wong

Topic Mesothelioma, Thymoma & Other Thoracic Tumors

Keywords

surgical resection

induction chemotherapy

survival outcomes

malignant pleural mesothelioma

comorbidity scores

Cox proportional hazards modeling

5-year survival

adjuvant treatment

delaying surgery

best treatment approach