2023 World Conference on Lung Cancer (Posters)-EP14.01. Risk Factors Influencing Postoperative Pleural Empyema in Patients with Pleural Mesothelioma after Multimodal Therapy

EP14.01. Risk Factors Influencing Postoperative Pleural Empyema in Patients with Pleural Mesothelioma after Multimodal Therapy - PDF(Slides)

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A retrospective analysis was conducted to identify risk factors for postoperative pleural empyema in patients with malignant pleural mesothelioma (PM) who underwent surgery. The study included 400 patients who underwent surgery at the University Hospital of Zurich. Of these, 50 patients (12.5%) developed postoperative empyema within 90 days. <br /><br />The study found that patients who underwent extrapleural pneumonectomy (EPP) had a higher risk of developing empyema compared to those who underwent other surgical procedures such as pleurectomy and decortication (P/D), extended P/D (EP/D), partial pleurectomy, or explorative thoracotomy. Diaphragm replacement with prosthetic material, such as Goretex, was also identified as a risk factor for empyema. <br /><br />The median overall survival was similar between patients with and without empyema, but there was a trend towards slightly lower survival in the empyema group. However, the difference was not statistically significant. <br /><br />The study concludes that EPP and the use of prosthetic material for diaphragm replacement increase the risk of developing postoperative empyema in patients with PM. In contrast, P/D and EP/D procedures are associated with fewer cases of empyema. The management of postoperative empyema with recurrent dressing changes may lead to prolonged hospitalization and potentially reduce quality of life. <br /><br />The study emphasizes the need for further research to identify additional risk factors for postoperative pleural empyema in order to improve surgical outcomes in patients with PM.

Asset Subtitle

Sven Hillinger

Meta Tag

Speaker Sven Hillinger

Topic Mesothelioma, Thymoma & Other Thoracic Tumors

Keywords

retrospective analysis

risk factors

postoperative pleural empyema

malignant pleural mesothelioma

surgery

University Hospital of Zurich

extrapleural pneumonectomy

pleurectomy and decortication

diaphragm replacement

prosthetic material