2023 World Conference on Lung Cancer (Posters)-EP14.03. Expression of Fibroblast Activation Protein in Intrathoracic Solitary Fibrous Tumor

EP14.03. Expression of Fibroblast Activation Protein in Intrathoracic Solitary Fibrous Tumor - PDF(Abstract)

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This study focuses on the expression of Fibroblast Activation Protein (FAP) in intrathoracic Solitary Fibrous Tumors (SFTs). FAP is a serine protease that has been found to be expressed in various types of cancer and is associated with prognosis in cancer patients. The researchers conducted a retrospective study on 13 patients who underwent surgery for intrathoracic SFTs. They evaluated the expression of FAP in tumor sections using immunohistochemical staining.<br /><br />The study found that most intrathoracic SFTs expressed FAP, suggesting that it could be a potential diagnostic and therapeutic target for SFTs. However, caution should be exercised when interpreting the results of diagnostic methods targeting FAP, as there may be SFTs that are negative for FAP.<br /><br />The patients in the study were predominantly male, with a median age of 64 years. The tumors varied in size and location, with some originating from the visceral pleura and others from the parietal pleura. Surgical procedures included partial resection of the lung, tumor resection, lobectomy, and partial resection of the diaphragm. Pathological findings showed varying levels of Ki67, a protein associated with cell proliferation, with most cases showing 1-5% expression. FAP was expressed in 12 out of 13 cases, with one tumor showing high malignant potential and strong FAP expression. Additionally, a tumor that showed FAP expression on FAP inhibitor PET imaging had a SUVmax of 2.0.<br /><br />This study adds to the understanding of the potential role of FAP as a diagnostic and therapeutic target for intrathoracic SFTs. Further research is needed to explore the implications of FAP expression in the management of these tumors.

Asset Subtitle

Toru Kimura

Meta Tag

Speaker Toru Kimura

Topic Other Thoracic Malignancy

Keywords

Fibroblast Activation Protein

intrathoracic Solitary Fibrous Tumors

serine protease

cancer prognosis

retrospective study

immunohistochemical staining

diagnostic target

therapeutic target

male patients

Ki67 protein