2023 World Conference on Lung Cancer (Posters)-EP14.03. Implant Associated Squamous Cell Carcinoma: An Emerging Chest Wall Malignancy

EP14.03. Implant Associated Squamous Cell Carcinoma: An Emerging Chest Wall Malignancy - PDF(Abstract)

Pdf Summary

A study conducted by researchers at MD Anderson Cancer Center in Houston has identified cases of breast implant-associated squamous cell carcinoma (BIA-SCC), an emerging form of chest wall malignancy. The study aimed to define the characteristics, diagnosis, and treatment of BIA-SCC. A total of 21 cases of BIA-SCC and 6 cases of squamous cell metaplasia were identified. The average time from implant placement to diagnosis was 25.3 years. Most patients presented with an invasive thoracic wall mass, swelling, or seroma, and sternal pain. Imaging showed a complex fluid collection around the implant, and fluid aspiration identified squamous cells in some cases. The majority of patients had a mass extending beyond the implant capsule, and some had regional lymph node involvement. Treatment involved a combination of surgery, chemotherapy, and radiation. After an average follow-up of 22.2 months, 33.3% of patients were disease-free, 14.3% had ongoing disease, 14.3% died of the disease, and 38.1% were lost to follow-up. BIA-SCC is considered to be a rare but aggressive complication of breast implants, with a high mortality rate in the short-term. It is unclear if squamous cell metaplasia represents a precursor lesion or if specific types of implants play a role in the development of BIA-SCC. Clinicians should be aware of the potential risk of BIA-SCC and consider it in the differential diagnosis of patients with breast implants presenting with a mass or other suspicious symptoms. Further research is needed to better understand the causes and optimal management of this rare complication.

Asset Subtitle

Mark Clemens

Meta Tag

Speaker Mark Clemens

Topic Other Thoracic Malignancy

Keywords

breast implant-associated squamous cell carcinoma

BIA-SCC

chest wall malignancy

diagnosis of BIA-SCC

characteristics of BIA-SCC

treatment of BIA-SCC

squamous cell metaplasia

implant placement

thoracic wall mass

breast implant complications