2023 World Conference on Lung Cancer (Posters)-EP14.03. Implant Associated Squamous Cell Carcinoma: An Emerging Chest Wall Malignancy

EP14.03. Implant Associated Squamous Cell Carcinoma: An Emerging Chest Wall Malignancy - PDF(Slides)

Pdf Summary

Breast implant-associated squamous cell carcinoma (BIA-SCC) is a rare and aggressive complication of breast implants. It has been identified as a distinct form of cancer associated with breast implants, similar to breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The average time from implant placement to diagnosis of BIA-SCC was 25.3 years.<br /><br />The most common symptoms of BIA-SCC were an invasive thoracic wall mass, swelling or seroma, and sternal pain. Imaging showed a complex fluid collection around the implant, and squamous cells were identified in fluid samples in some cases. The majority of patients had a mass extending beyond the implant capsule, and a small percentage had lymph node involvement.<br /><br />Treatment for BIA-SCC typically involved a combination of surgery, chemotherapy, and radiation. However, recurrence of the disease was common. After an average follow-up of 22.2 months, 33.3% of patients were disease-free, 14.3% had ongoing disease, 14.3% died from the disease, and 38.1% were lost to follow-up.<br /><br />The exact cause of BIA-SCC is still unclear, but it is suspected that the Epstein-Barr virus (EBV) plays a role in its development. It is also unknown if squamous cell metaplasia (SCM) represents a precursor lesion for BIA-SCC or if certain types of implants are more likely to trigger the development of BIA-SCC.<br /><br />Healthcare professionals should be aware of the potential risk of BIA-SCC and consider it in the differential diagnosis of patients with breast implants presenting with a mass or other suspicious symptoms. Further research is needed to better understand the causes and optimal management of this rare complication.

Asset Subtitle

Mark Clemens

Meta Tag

Speaker Mark Clemens

Topic Other Thoracic Malignancy

Keywords

Breast implant-associated squamous cell carcinoma

BIA-SCC

complication

breast implants

cancer

symptoms

diagnosis

treatment

recurrence

risk