2023 World Conference on Lung Cancer (Posters)-EP17.04. Lung Stereotactic Body Radiation Therapy in a Developing Country: Patterns of Safety and Treatment Toxicities

EP17.04. Lung Stereotactic Body Radiation Therapy in a Developing Country: Patterns of Safety and Treatment Toxicities - PDF(Abstract)

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This study aimed to analyze the safety and treatment toxicities of lung stereotactic body radiation therapy (SBRT) in a developing country. The researchers retrospectively analyzed the clinical profile, treatment effects, and safety of up to 10 fractions of pulmonary SBRT in selected patients treated over a period of 30 months. The data was statistically analyzed for demographic standards, and clinical profiles, dosimetric parameters, adverse effects, and post-radiotherapy differences were evaluated.<br /><br />A total of 27 individuals received pulmonary SBRT, with a maximum of 10 days of treatment. The majority of patients were women and non-smokers. All patients were required to cease smoking during and after treatment. Acute adverse effects were experienced by 12 patients, but no grade 5 CTAE (Common Terminology Criteria for Adverse Events) were observed. Reported toxicities included cough, dyspnea, hemoptysis, and rib fracture.<br /><br />The minimum total dose administered was 800cGy in a single dose/day, while the maximum was 6000cGy within 8 days. The patients had various types of cancer, including lung metastases from the colon, metastases from the breast, and primary lung cancer. Metastatic lung cancers required a higher dose of radiation, with the lowest dose being 3000cGy fractionated over 5 days for breast cancer metastases and 6000cGy fractionated over 8 days for lung metastases.<br /><br />Seven deaths were reported after SBRT, and 17 patients are alive after treatment. The study concludes that SBRT using 1,3,5,8, or 10 fractions is a safe and effective treatment option for selected patients in developing countries, aligning with published data on survival and toxicities.

Asset Subtitle

Renne Augusto Bart Aguiar

Meta Tag

Speaker Renne Augusto Bart Aguiar

Topic Global Health, Health Services & Health Economics: Real World Data

Keywords

lung stereotactic body radiation therapy

developing country

clinical profile

treatment effects

safety

pulmonary SBRT

adverse effects

dosimetric parameters

CTAE

metastatic lung cancers