2023 World Conference on Lung Cancer (Posters)-P1.01. Peptic Ulcer and Long-Term Risk of Lung Cancer: A Prospective Cohort Study from UK Biobank

P1.01. Peptic Ulcer and Long-Term Risk of Lung Cancer: A Prospective Cohort Study from UK Biobank - PDF(Abstract)

Pdf Summary

A large prospective cohort study from the UK Biobank has found that peptic ulcer (PU) is associated with an increased risk of lung cancer in people with a history of smoking. The study followed 110,860 participants for an average of 13.3 years and identified 135 cases of incident lung cancer in patients with PU, compared to 1,988 cases in reference individuals. The adjusted hazard ratio for lung cancer was 1.21 among PU patients compared to non-PU patients. The association was specifically observed in gastric ulcer patients, while duodenal ulcer was not associated with lung cancer risk. Furthermore, PU in the active phase and of 5 to 15 years' duration were associated with a more significant risk of lung cancer. Subgroup analysis revealed that populations with previously low lung cancer risk, such as those with a high BMI, former smokers, and light smokers, had a higher risk of lung cancer incidence. It is recommended that when clinically screening for lung cancer, attention should be paid to patients with active and/or long-standing peptic ulcers, and early medical care should be provided to prevent lung cancer occurrence.

Asset Subtitle

Zhuangzhuang Liu

Meta Tag

Speaker Zhuangzhuang Liu

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

prospective cohort study

peptic ulcer

lung cancer

smoking

participants

gastric ulcer

adjusted hazard ratio

active phase

duration

subgroup analysis