2023 World Conference on Lung Cancer (Posters)-P1.03. Dynamic Transcriptomic Characterization Changes of Early Stage Lung Adenocarcinoma as per the Incrassation of Consolidation Tumor Ratio

P1.03. Dynamic Transcriptomic Characterization Changes of Early Stage Lung Adenocarcinoma as per the Incrassation of Consolidation Tumor Ratio - PDF(Abstract)

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This study explores the transcriptomic changes in early-stage lung adenocarcinoma (es-LUAD) based on the consolidation tumor ratio (CTR). Tumor tissues were collected from 195 patients with es-LUAD for mRNA sequencing, and the TCGA-LUAD mRNA dataset was also analyzed. The patients were divided into two groups based on CTR. Differential expression analysis revealed 1716 upregulated genes and 1207 downregulated genes with increasing CTR. Among these, 615 upregulated genes and 393 downregulated genes were specific to CTR compared to other factors such as histology subtypes, N status, and M status. Enrichment analysis showed that RNA metabolic pathways were upregulated while cell-cell adhesion pathways were downregulated. The upregulated genes in higher CTR es-LUAD were associated with aggressive gene sets and cell-cycle-related gene sets. The findings suggest that with increasing CTR, more genes related to tumor aggression are upregulated, and cells within higher CTR lesions are more likely to undergo metastasis and proliferation. This study further confirms the clinical relevance of CTR in distinguishing tumor invasiveness at the transcriptome level.

Asset Subtitle

Zhen-bin Qiu

Meta Tag

Speaker Zhen-bin Qiu

Topic Tumor Biology: Preclinical Biology - Omics Approaches

Keywords

transcriptomic changes

lung adenocarcinoma

early-stage

CTR

consolidation tumor ratio

mRNA sequencing

TCGA-LUAD

differential expression analysis

upregulated genes

downregulated genes