2023 World Conference on Lung Cancer (Posters)-P1.06. Effect and Mechanism of ASNS Remodeling the Metastatic Lymph Node Immune Microenvironment in Lung Cancer

P1.06. Effect and Mechanism of ASNS Remodeling the Metastatic Lymph Node Immune Microenvironment in Lung Cancer - PDF(Abstract)

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This study aims to investigate the effect and mechanism of asparagine synthetase (ASNS) in remodeling the immune microenvironment in metastatic lymph nodes (LNs) in lung cancer. The authors analyzed the expression of ASNS and its relationship to immunogenicity in primary tumors and metastatic LNs in non-small cell lung cancer (NSCLC) patients and murine models. They found that the ASNS expression was significantly higher in lung cancer cells in metastatic LNs compared to primary tumors. The lung cancer cells with high ASNS expression showed enhanced immunogenicity through the autocrine α-aminobutyric acid. In murine models, the ASNS-wildtype group exhibited increased CD44 CD62L CD8T cells (activated memory phenotypes) in primary tumors and metastatic LNs, and this improvement in anti-tumor activity was confirmed by in vitro co-culture experiments. Therefore, the study suggests that high ASNS expression in lung cancer cells promotes T cell activation and memory in metastatic LNs through immunogenicity enhancement and asparagine paracrine secretion. These findings elucidate the role of ASNS in immune remodeling in metastatic LNs and provide insights into potential therapeutic strategies for lung cancer.

Asset Subtitle

Min Li

Meta Tag

Speaker Min Li

Topic Tumor Biology: Preclinical Biology - Tumor Immunity

Keywords

asparagine synthetase

ASNS

immune microenvironment

metastatic lymph nodes

lung cancer

immunogenicity

non-small cell lung cancer

NSCLC

CD44 CD62L CD8T cells

anti-tumor activity