2023 World Conference on Lung Cancer (Posters)-P1.09. Anti-Cancer Immune Activation Post Bronchoscopic Thermal Ablation in Non-Small Cell Lung Cancer

P1.09. Anti-Cancer Immune Activation Post Bronchoscopic Thermal Ablation in Non-Small Cell Lung Cancer - PDF(Abstract)

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This presentation at the WCLC 2023 conference discussed the findings of a study on the immune response following bronchoscopic thermal ablation (BTVA) in non-small cell lung cancer (NSCLC). BTVA is a minimally invasive technique that uses heat to destroy tumors. The study aimed to determine if BTVA could activate an anti-cancer immune response that could enhance the efficacy of immune checkpoint inhibitor (ICI) therapy in NSCLC.<br /><br />The study included five patients with stage I NSCLC who underwent BTVA as part of a clinical trial. After ablation, the patients underwent surgical resection. Tissue samples from before and after ablation, as well as blood samples, were collected for analysis.<br /><br />The analysis of gene expression in the tumor microenvironment (TME) showed a significant increase in genes associated with antigen presentation and T cell trafficking and activation. Specifically, markers consistent with monocyte-derived dendritic cells and genes associated with MHC II were upregulated. There was also an increase in CD4 T cells and macrophages in the injured tumor area compared to other areas.<br /><br />CyTOF analysis of blood samples showed an increase in CD4 and CD8 central memory T cells, indicating immune memory reactivation.<br /><br />Overall, the study suggests that BTVA can activate a T cell-mediated immune response in NSCLC, characterized by increased antigen presentation, T cell trafficking, and activation in the TME. This immune response appears to be tumor-specific, as observed by the increase in immune cells within the injured tumor. These findings support the idea that BTVA could enhance the efficacy of ICI therapy in NSCLC.<br /><br />Keywords: Ablation, non-small cell lung cancer, cancer immunity

Asset Subtitle

Kanishka Rangamuwa

Meta Tag

Speaker Kanishka Rangamuwa

Topic Tumor Biology: Translational Biology - IO

Keywords

Ablation

non-small cell lung cancer

cancer immunity

bronchoscopic thermal ablation

immune response

immune checkpoint inhibitor therapy

gene expression

tumor microenvironment

antigen presentation

T cell trafficking