2023 World Conference on Lung Cancer (Posters)-P1.09. Anti-Cancer Immune Activation Post Bronchoscopic Thermal Ablation in Non-Small Cell Lung Cancer

P1.09. Anti-Cancer Immune Activation Post Bronchoscopic Thermal Ablation in Non-Small Cell Lung Cancer - PDF(Slides)

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A new study suggests that bronchoscopic thermal vapour ablation (BTVA) can induce an anti-cancer immune response in non-small cell lung cancer (NSCLC). BTVA is a minimally invasive ablation technique that creates areas of tissue necrosis. The study found that gene expression was significantly altered following BTVA, with an increase in genes associated with antigen presentation, monocyte derived dendritic cells, MHC II, and T cell trafficking and activation. Tissue analysis showed an increase in CD4 T cells and macrophages within the injured tumor. Blood analysis demonstrated an increase in neutrophils and type 1 dendritic cells, as well as an increase in CD4 and CD8 central memory T cell subsets. These findings suggest that there is activation of a T cell-mediated immune response in the tumor microenvironment (TME) following BTVA. The proliferation of CD4 and CD8 central memory T cells in the blood indicates immune memory reactivation. However, further studies with a larger patient number are needed to confirm these findings. The study utilized pre- and post-ablation tissue samples and blood samples from patients with stage I NSCLC undergoing BTVA. RNA sequencing and multiplex ion beam imaging were used to analyze gene expression and immune cell populations, respectively. Mass cytometry analysis was performed on blood samples to assess systemic immune changes. Overall, this study provides preliminary evidence that BTVA can activate an anti-cancer immune response in NSCLC.

Asset Subtitle

Kanishka Rangamuwa

Meta Tag

Speaker Kanishka Rangamuwa

Topic Tumor Biology: Translational Biology - IO

Keywords

bronchoscopic thermal vapour ablation

anti-cancer immune response

NSCLC

gene expression

T cell trafficking

CD4 T cells

macrophages

tumor microenvironment

immune memory reactivation

RNA sequencing