2023 World Conference on Lung Cancer (Posters)-P1.09. Characterization of the Expression of BTN1A1 Exclusive to PD-L1/PD-1 Axis in Small Cell Lung Cancer Using Spatial Biology Approach

P1.09. Characterization of the Expression of BTN1A1 Exclusive to PD-L1/PD-1 Axis in Small Cell Lung Cancer Using Spatial Biology Approach - PDF(Abstract)

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This document summarizes a presentation titled "Characterization of the Expression of BTN1A1 Exclusive to PD-L1/PD-1 Axis in Small Cell Lung Cancer Using Spatial Biology Approach" that was presented at the WCLC 2023 conference. The study aimed to investigate the expression of the immune regulatory molecule BTN1A1 in small cell lung cancer (SCLC) using spatial transcriptomics and multiplex immunofluorescence. The researchers mapped the expression of BTN1A1 and PD-L1 in SCLC patient samples and found a distinct spatial pattern of BTN1A1 expression in both cancer cells and tumor-associated immune cells. There was a strong correlation between BTN1A1 expression and specific immune cell populations, suggesting its role in regulating the tumor immune microenvironment. The study provides valuable insights into BTN1A1's expression patterns in SCLC and its role in immune regulation and evasion. The researchers recommend the development and optimization of anti-BTN1A1 antibody therapies, with a focus on understanding treatment response and resistance factors. The promising results from the Phase I clinical trial of a humanized monoclonal antibody targeting BTN1A1 suggest potential treatment directions for small cell lung tumors. The integration of spatial biology approaches with other cutting-edge technologies, such as single-cell sequencing and computational modeling, could enhance our understanding of tumor-immune interactions and facilitate the discovery of novel therapeutic targets in cancer immunotherapy. Overall, the study highlights the significance of understanding BTN1A1 expression and its potential as a target for personalized immunotherapy strategies in advanced SCLC.

Asset Subtitle

Stephen Yoo

Meta Tag

Speaker Stephen Yoo

Topic Tumor Biology: Translational Biology - IO

Keywords

BTN1A1

PD-L1

Spatial Biology Approach

Small Cell Lung Cancer

Tumor Microenvironment

Immune Regulation

Anti-BTN1A1 Antibody Therapies

Phase I Clinical Trial

Therapeutic Targets

Cancer Immunotherapy