2023 World Conference on Lung Cancer (Posters)-P1.13. Proof-of-mechanism for a Diagnostic Probe Generating D5-Ethanol Asan On-Breath Reporter Molecule for Lung Cancer - Evolution Phase 1.

P1.13. Proof-of-mechanism for a Diagnostic Probe Generating D5-Ethanol Asan On-Breath Reporter Molecule for Lung Cancer - Evolution Phase 1. - PDF(Slides)

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A study conducted by Owlstone Medical Ltd. evaluated the potential of exogenous volatile organic compound (EVOC) probes in generating breath-based signals for lung cancer diagnosis. The study focused on targeting β-glucuronidase, an enzyme associated with lung cancer, using D5-ethyl-β-D-glucuronide as an EVOC probe. Tissue analysis of 140 lung tissue samples demonstrated the differential expression of β-glucuronidase in lung cancer cells and tumor microenvironment components. A phase 1a study involving 21 healthy controls showed that administration of the EVOC probe was safe and well-tolerated. In a phase 1b study involving 31 participants (12 lung cancer patients and 19 healthy controls), D5-ethyl-β-D-glucuronide was administered intravenously, and breath samples were collected. Preliminary results showed the detection of D5-ethanol, a product of the cleavage of the EVOC probe, in breath samples of a subset of individuals. Safety and tolerability of the EVOC probe were confirmed in both phases of the study, with no serious adverse events reported. These findings lay the foundation for a phase 2 study to further explore the diagnostic performance of this breath test approach for lung cancer. The study highlights the potential of EVOC probes in harnessing metabolic pathways associated with breath biomarkers for the sensitive and specific detection of lung cancer.

Asset Subtitle

Marc Schee

Meta Tag

Speaker Marc Schee

Topic Screening & Early Detection: Biomarkers/Imaging Technology

Keywords

study

Owlstone Medical Ltd.

exogenous volatile organic compound

EVOC probes

lung cancer diagnosis

β-glucuronidase

D5-ethyl-β-D-glucuronide

tissue analysis

phase 1a study

phase 1b study