2023 World Conference on Lung Cancer (Posters)-P1.16. Transbronchial Cryobiopsy Using 1.1 mm-Diameter Cryoprobe for the Diagnosis of Early Stage Lung Cancer

P1.16. Transbronchial Cryobiopsy Using 1.1 mm-Diameter Cryoprobe for the Diagnosis of Early Stage Lung Cancer - PDF(Slides)

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A study was conducted to assess the efficacy and safety of transbronchial cryobiopsy (TBCB) using a 1.1-mm diameter cryoprobe for the diagnosis of early stage lung cancer. Traditionally, bronchoscopic biopsy forceps were used to sample peripheral lung lesions (PLLs) after confirming their location using radial probe endobronchial ultrasound (RP-EBUS). However, the diagnostic yield with this method was limited. The study aimed to increase the diagnostic yield by using a smaller cryoprobe. <br /><br />The study included 50 patients with PLLs less than or equal to 30 mm who had no established diagnosis of PLLs and were planned for RP-EBUS. A 1.1-mm diameter cryoprobe was inserted under fluoroscopic guidance, and up to three cryobiopsies were performed per patient. The diagnostic yield of TBCB and adverse events related to the bronchoscopy procedures were the primary and secondary outcomes, respectively.<br /><br />The results showed a histopathological diagnostic yield of 90% for TBCB, with no difference in yield based on the size or location of the PLLs. There were no iatrogenic pneumothorax, procedure-related lung infections, or unexpected life-threatening complications. Bleeding occurred in 82% of patients, but all cases were mild to moderate and were successfully controlled with therapeutic bronchoscopy.<br /><br />In conclusion, TBCB using a 1.1-mm diameter cryoprobe is an effective and safe method for diagnosing PLLs, regardless of size or anatomical location. The study suggests that this approach can increase the diagnostic yield compared to traditional methods.

Asset Subtitle

Jung Seop Eom

Meta Tag

Speaker Jung Seop Eom

Topic Screening & Early Detection: Nodule Management

Keywords

transbronchial cryobiopsy

TBCB

1.1-mm diameter cryoprobe

lung cancer diagnosis

bronchoscopic biopsy forceps

peripheral lung lesions

radial probe endobronchial ultrasound

RP-EBUS

diagnostic yield

adverse events