2023 World Conference on Lung Cancer (Posters)-P1.17. Cost-Effectiveness of LDCT Screening in Never Smokers at High Lung-Cancer Risk

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This document summarizes a presentation titled "Cost-Effectiveness of LDCT Screening in Never Smokers at High Lung-Cancer Risk" from the WCLC 2023 conference. The presentation discusses the cost-effectiveness of low-dose computed tomography (LDCT) screening for early detection of lung cancer in high-risk individuals. The study evaluated the first-round screening (T0) results of the Taiwan Lung Cancer Screening for Never Smoker Trial (TALENT) and developed a decision tree model to compare LDCT screening with no screening from a societal perspective.<br /><br />Using a lifetime horizon, the researchers calculated the incremental cost-effectiveness ratio (ICER) of LDCT screening. The expected number of lung cancer cases in the no-screening group was estimated based on incidence rates and demographic factors. The findings showed that LDCT screening was cost-effective, with ICERs of $47,860, $33,943, and $89,064 per quality-adjusted life year (QALY) for all participants, participants with a family history of lung cancer, and participants without a family history, respectively.<br /><br />The study also identified key factors influencing the cost-effectiveness, including the utility of early-stage lung cancer, the rate of positive LDCT screening, and the cost of LDCT. The researchers found that LDCT screening had probabilities of being cost-effective of 38.7%, 51.4%, and 27.9% for all participants, participants with a family history, and participants without a family history, respectively, when considering a willingness-to-pay threshold.<br /><br />The conclusion of the study is that LDCT screening is a cost-effective strategy in Taiwan for never smokers with a family history of lung cancer. The researchers suggest that further studies based on repeated screenings are needed to validate these results.

Asset Subtitle

Szu-Chun Yang

Meta Tag

Speaker Szu-Chun Yang

Topic Screening & Early Detection: Program Design

Keywords

Cost-Effectiveness

LDCT Screening

Never Smokers

High Lung-Cancer Risk

Taiwan Lung Cancer Screening for Never Smoker Trial

Decision Tree Model

Incremental Cost-Effectiveness Ratio

Quality-Adjusted Life Year

Family History of Lung Cancer

Willingness-to-Pay Threshold