2023 World Conference on Lung Cancer (Posters)-P1.17. Cost-effectiveness of Low-dose Computerized Tomography Lung Cancer Screening in High-risk Non-smokers and Smokers in Hong Kong

P1.17. Cost-effectiveness of Low-dose Computerized Tomography Lung Cancer Screening in High-risk Non-smokers and Smokers in Hong Kong - PDF(Abstract)

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This study investigates the cost-effectiveness of low-dose computerized tomography (LDCT) lung cancer screening in high-risk non-smokers and smokers in Hong Kong. The authors highlight that lung cancer is a significant health issue in Hong Kong, accounting for a large number of new cancer cases and cancer-related deaths. While LDCT screening for high-risk individuals has been recommended to reduce mortality, there is limited cost-effectiveness (CE) data for screening high-risk non-smokers in East Asia. <br /><br />To address this, a CE analysis was conducted using a decision tree and state-transition Markov model. The analysis simulated the identification, diagnosis, and treatment of high-risk individuals, both smokers and non-smokers, from a healthcare provider perspective. The selection criteria for smokers were based on the Dutch-Belgian Randomized Lung Cancer Screening (NELSON) study, while the Taiwan Lung Cancer Screening in Never-Smoker Trial (TALENT) was utilized to model non-smokers. Local lung cancer survival rates and costs were included in the model. <br /><br />The results of the analysis showed that LDCT screening led to the detection of more early lung cancers, increased life-years, and a reduction in lung cancer mortality compared to no screening. In the high-risk smoking population, the incremental cost-effectiveness ratio (ICER) was reported to be USD 12,969 per Quality-adjusted life year (QALY), while in high-risk non-smokers, the ICER was USD 7,632 per QALY. <br /><br />Based on these findings, the authors conclude that LDCT lung cancer screening is cost-effective in both high-risk smokers and non-smokers in Hong Kong. They suggest that a population-based screening approach should be considered for all high-risk individuals, including non-smokers. The results of this study may also hold relevance for other East Asian countries with similar lung cancer epidemiology and demographics. Overall, the study provides insight into the potential benefits of LDCT screening in reducing lung cancer mortality in high-risk individuals.

Asset Subtitle

Herbert Loong

Meta Tag

Speaker Herbert Loong

Topic Screening & Early Detection: Program Design

Keywords

LDCT lung cancer screening

cost-effectiveness

high-risk non-smokers

high-risk smokers

Hong Kong

lung cancer

CE analysis

smoking population

incremental cost-effectiveness ratio

QALY