2023 World Conference on Lung Cancer (Posters)-P1.17. Cost-effectiveness of Low-dose Computerized Tomography Lung Cancer Screening in High-risk Non-smokers and Smokers in Hong Kong

P1.17. Cost-effectiveness of Low-dose Computerized Tomography Lung Cancer Screening in High-risk Non-smokers and Smokers in Hong Kong - PDF(Slides)

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LC screening with low-dose computed tomography (LDCT) is recommended by medical organizations to reduce mortality in high-risk groups defined by age and smoking behaviors. However, there is a lack of cost-effectiveness (CE) data for screening high-risk non-smokers. Therefore, a CE analysis was conducted in Hong Kong (HK) to assess the effectiveness and cost-effectiveness of LDCT screening in both high-risk smokers and non-smokers.<br /><br />The analysis used local data and modeled the screening criteria and effectiveness for smokers based on the Dutch-Belgian Randomized Lung Cancer Screening (NELSON) study, and for non-smokers based on the Taiwan Lung Cancer Screening in Never-Smoker Trial (TALENT). The simulation model included the identification, diagnosis, and treatments for a high-risk population.<br /><br />The findings showed that screening with LDCT led to the detection of more early lung cancers, increased life-years gained, and a reduction in lung cancer mortality compared to no screening. The incremental cost-effectiveness ratio (ICER) for high-risk smokers was $14,723 per Quality-adjusted life year (QALY), and for high-risk non-smokers, it was $10,096 per QALY. These results suggest that LDCT screening is cost-effective in HK for both high-risk smokers and non-smokers.<br /><br />The study supports a population-based screening approach that includes all high-risk individuals, beyond just smokers. The findings are applicable not only to HK but also to other East Asian countries with similar lung cancer epidemiological and demographical profiles.<br /><br />In conclusion, LDCT screening with CE is considered cost-effective in HK for high-risk smokers and non-smokers, leading to population health gains. These results emphasize the importance of expanding screening programs to include all individuals at high risk for lung cancer.

Asset Subtitle

Herbert Loong

Meta Tag

Speaker Herbert Loong

Topic Screening & Early Detection: Program Design

Keywords

LC screening

low-dose computed tomography

mortality reduction

high-risk groups

cost-effectiveness

smokers

non-smokers

QALY

population health gains