2023 World Conference on Lung Cancer (Posters)-P1.24. Prognostic Molecular and Genetic Factors in Early Stage Non Small Cell Lung Cancer

Pdf Summary

This study focuses on identifying prognostic molecular and genetic factors in early stage non-small cell lung cancer (NSCLC). The authors conducted a review of literature to explore the evolution and refinement of molecular predictors for prognosis in lung carcinoma. They aimed to establish the relationship between biological molecular parameters and prognosis in NSCLC.<br /><br />A total of 78 patients who underwent surgery for stage IA-IIIA NSCLC were included in the study. Patient data including demographics, respiratory parameters, laboratory data, clinical data, and postoperative pathological data were recorded. Tumor tissue samples were taken for genetic analysis of various genetic polymorphisms.<br /><br />The study found that the presence of EGFR exon 19 mutations was associated with a higher 5-year survival rate compared to patients without these mutations. Additionally, mutations in TRAIL (tumor-necrosis factor-related apoptosis-inducing ligand) and its death receptors TRAIL-R1 and TRAIL-R2 were not associated with patient survival. However, patients with specific mutations in TRAIL-C achieved higher 5-year survival rates.<br /><br />The study also revealed a correlation between T status (T1A, T1B, T2A, T2B) and the presence of EGFR mutations, suggesting that these mutations could be used as a prognostic factor. Furthermore, N status (nodal involvement) was found to be associated with both EGFR and TRAIL-C mutation status.<br /><br />In conclusion, EGFR and TRAIL-C mutations were found to be independently associated with survival in early stage NSCLC patients. These mutations were also associated with nodal involvement in lung cancer. The authors suggest that evaluating biological parameters in addition to TNM staging could be important for survival prognosis in the future.<br /><br />Overall, this study provides valuable insights into the prognostic molecular and genetic factors that can be used to improve the understanding and management of early stage NSCLC.

Asset Subtitle

Gizem Özçibik Isik

Meta Tag

Speaker Gizem Özçibik Isik

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

prognostic factors

molecular factors

genetic factors

early stage

non-small cell lung cancer

NSCLC

literature review

genetic analysis

EGFR mutations

TRAIL-C mutations