2023 World Conference on Lung Cancer (Posters)-P1.24. Single-Cell Profiling Reveals the Trajectory of FOLR2+TAMs to Tregs in the Progression of Lung Adenocarcinoma

P1.24. Single-Cell Profiling Reveals the Trajectory of FOLR2+TAMs to Tregs in the Progression of Lung Adenocarcinoma - PDF(Abstract)

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This study aimed to investigate the cellular mechanism underlying the formation of an immunosuppressive microenvironment in lung adenocarcinoma (LUAD). The researchers used single-cell RNA sequencing to analyze LUAD samples from different stages of the disease, as well as normal lung samples. They found that myeloid cells and T cells were the most abundant cell types in both tumors and normal lung tissues. However, FOLR2TAM and NR4A3CD4 showed significant increases in invasive adenocarcinoma (IA). The researchers also observed upregulation of CCL17/19/22 expressions in IA and dendritic cells (DCs), which were associated with FOLR2TAM. It was found that FOLR2TAM cells are recruited by chemokines secreted by DCs, which in turn attract NR4A3CD4 cells. Furthermore, the researchers discovered that NR4A3CD4 cells have the potential to convert into regulatory CD4 T lymphocytes (Tregs), which play a role in the immunosuppressive microenvironment. The study reveals a trajectory of FOLR2TAM cells being recruited by chemokines secreted by DCs, attracting NR4A3CD4 cells, and promoting their conversion into Tregs. This cellular pathway is involved in shaping the immune suppressive microenvironment during the progression of LUAD. Overall, this research provides insight into how the cellular components of the tumor microenvironment contribute to the progression of lung adenocarcinoma.

Asset Subtitle

Yuchen Han

Meta Tag

Speaker Yuchen Han

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

cellular mechanism

immunosuppressive microenvironment

lung adenocarcinoma

LUAD

single-cell RNA sequencing

FOLR2TAM

NR4A3CD4

invasive adenocarcinoma

chemokines

Tregs