2023 World Conference on Lung Cancer (Posters)-P1.24. The Association of Acinar Pattern with Clinicopathological, Molecular Features, and Prognosis in Lung Adenocarcinoma Patients

P1.24. The Association of Acinar Pattern with Clinicopathological, Molecular Features, and Prognosis in Lung Adenocarcinoma Patients - PDF(Slides)

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This study examines the association between different levels of the acinar pattern in lung adenocarcinoma (LUAD) and clinicopathological characteristics, molecular features, and clinical outcomes. Surgically resected LUAD samples were obtained from the IUCPQ Biobank-Quebec Research Respiratory Health Network. The samples were divided into three groups: Acinar Predominant (AP), Acinar Component (AC), and Acinar Negative (AN). Targeted sequencing was performed to detect mutations/rearrangements in common genes. Overall survival (OS) was analyzed using various statistical methods. <br />The results showed that having at least a 5% acinar component is an independent indicator of poor prognosis in LUAD, regardless of gene mutational status, pathological staging, and other histological subtypes. The study included a total of 1103 LUAD patients, with 605 AP, 466 AC, and 32 AN. The most frequent driver mutation detected was KRAS. <br />The study also found a significant association between the acinar pattern and other histological subtypes in overall survival. The frequency of the acinar pattern was highest in the cohort. The difference in the frequency of common gene mutations/rearrangements was analyzed among the AP, AC, and AN patients. The study concludes that the presence of the acinar pattern is associated with a higher risk of worse overall survival in LUAD. <br />Overall, this comprehensive clinical investigation provides insights into the role of the acinar pattern in LUAD prognosis and highlights the importance of considering additional factors beyond gene mutational status and pathological staging.

Asset Subtitle

Hanie Abolfathi

Meta Tag

Speaker Hanie Abolfathi

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

acinar pattern

lung adenocarcinoma

clinicopathological characteristics

molecular features

clinical outcomes

surgically resected

IUCPQ Biobank-Quebec Research Respiratory Health Network

targeted sequencing

mutations/rearrangements

overall survival