2023 World Conference on Lung Cancer (Posters)-P1.25. Patient-Reported Outcomes and Exercise Capacity in a Real-Life Setting in Non-small Cell Lung Cancer Patients Undergoing Radiotherapy

P1.25. Patient-Reported Outcomes and Exercise Capacity in a Real-Life Setting in Non-small Cell Lung Cancer Patients Undergoing Radiotherapy - PDF(Slides)

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A study was conducted to understand the impact of stereotactic body radiotherapy (SBRT) on health-related quality of life (HRQoL), exercise capacity, and treatment-related toxicity in patients with early-stage non-small cell lung cancer (ES-NSCLC). The study involved ES-NSCLC patients with WHO 2 and no other malignancies in the 5 years prior to the NSCLC diagnosis who were planned to undergo SBRT.<br /><br />Clinicians and patients both mostly reported fatigue, cough, and dyspnea, but clinicians reported less toxicity than patients. Overall toxicity and dyspnea worsened over time, while pain, fatigue, and cough showed meaningful clinical improvements. However, changes in toxicity and HRQoL did not impact the functional capacity of the patients.<br /><br />Patient-reported overall HRQoL, as well as physical and emotional functioning, improved over time. Specific patients experienced meaningful improvements or deteriorations in toxicity or HRQoL domains.<br /><br />At baseline, patients had a moderate daily functioning score and an average 6-minute walking distance of 360 meters. There were no statistically significant differences in daily functioning or exercise capacity over time.<br /><br />The study findings suggest that SBRT has an impact on HRQoL and toxicity in ES-NSCLC patients. While overall toxicity and dyspnea worsened over time, improvements were observed in pain, fatigue, and cough. However, these changes did not affect the functional capacity of the patients. The findings also indicate that overall HRQoL and physical and emotional functioning improved over time, suggesting a positive impact of SBRT on these aspects of patient well-being.

Asset Subtitle

Yolande Lievens

Meta Tag

Speaker Yolande Lievens

Topic Early-Stage NSCLC: Changing Paradigms & Outcomes

Keywords

SBRT

health-related quality of life

HRQoL

exercise capacity

treatment-related toxicity

non-small cell lung cancer

fatigue

cough

dyspnea

patient well-being