2023 World Conference on Lung Cancer (Posters)-P1.26. Sublobar Resection is Equivalent to Lobectomy for Stage IA Adenocarcinoma Presenting as Subsolid Nodule

P1.26. Sublobar Resection is Equivalent to Lobectomy for Stage IA Adenocarcinoma Presenting as Subsolid Nodule - PDF(Slides)

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A study conducted by Sebron Harrison from Weill Cornell Medicine in the USA compared the oncological differences between patients receiving lobectomy and sub-lobar resection for stage IA adenocarcinoma presenting as sub-solid nodules measuring 3cm. The study utilized data from the International Early Lung Cancer Action Program (I-ELCAP), Initiative for Early Lung Cancer Research on Treatment (IELCART), and the Weill Cornell Medicine databases. <br /><br />The results showed that there were 624 patients with sub-solid lesions measuring 3cm who underwent resection, with 320 patients undergoing lobectomy and 304 patients undergoing sublobar resection. Of those who underwent sublobar resection, 61% had wedge resection and 39% had segmental resection. <br /><br />The primary outcome of interest was lung cancer-specific survival (LCS), and the secondary outcomes were disease-free survival (DFS) and overall survival (OS). The study found that LCS was 100% for lobectomy and 98.2% for sub-lobar resection, with no statistically significant difference. The DFS and OS were also comparable between the two groups. <br /><br />Based on these findings, the study suggests that sublobar resection is a preferred surgical strategy for patients with sub-solid lesions measuring 3cm. This indicates that lobectomy may be overly extensive as a treatment for these less aggressive sub-solid lung cancers. These results provide important insights for the optimal treatment approach for this specific group of patients.

Asset Subtitle

Sebron Harrison

Meta Tag

Speaker Sebron Harrison

Topic Early-Stage NSCLC: More Minimally Invasive Approaches

Keywords

oncological differences

lobectomy

sub-lobar resection

stage IA adenocarcinoma

sub-solid nodules

3cm

surgical strategy

lung cancer-specific survival

disease-free survival

treatment approach