2023 World Conference on Lung Cancer (Posters)-P1.28. Differential Kinetics of Blood and Immune Subpopulations for Cisplatin vs. Sensitizing Paclitaxel Radiotherapy in Locally Advanced Lung Cancer

P1.28. Differential Kinetics of Blood and Immune Subpopulations for Cisplatin vs. Sensitizing Paclitaxel Radiotherapy in Locally Advanced Lung Cancer - PDF(Abstract)

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This presentation discusses the differential kinetics of blood and immune subpopulations in locally advanced lung cancer patients receiving different treatment regimens. The study compares the effects of cisplatin-based chemoradiotherapy (CRT) and low-dose radiosensitizing paclitaxel CRT on peripheral blood cells and immune subpopulations.<br /><br />The researchers collected serial blood samples from patients before, during, and after chest radiotherapy (RT). The three treatment cohorts analyzed were chest-RT alone, cisplatin-CRT, and low-dose radiosensitizing paclitaxel-CRT. Blood counts, along with CD3, CD4, CD8, and CD19 immune cells, were measured using flow cytometry.<br /><br />The results showed that cisplatin-CRT caused profound myelosuppression during treatment (V2), resulting in significant reductions in erythrocytes, leukocytes, and platelets. In contrast, the paclitaxel-CRT cohort did not show significant declines in blood counts compared to the chest-RT alone group. CD19 (B-cell) and CD3 (T-cell) levels decreased during treatment in all cohorts, indicating a common effect of chest-RT on lymphocytes. However, cisplatin-CRT significantly reduced more neutrophils and CD19 cells during treatment compared to the other cohorts.<br /><br />There was no difference in total T-cell numbers among the three treatment cohorts, but the paclitaxel-CRT group had significantly decreased CD4 (helper T-cells) levels and increased CD8 (cytotoxic T-cell) levels during treatment, leading to a shift in the balance of T-cell subpopulations.<br /><br />In conclusion, cisplatin-CRT led to significant reductions in peripheral blood cell counts, particularly neutrophils and B cells, while low-dose radiosensitizing paclitaxel-CRT did not have a significant impact on blood counts. Additionally, paclitaxel-CRT selectively diminished CD4 cells, tilting the balance in T-cell subpopulations. The implications of this immune modulation on the balance of immune subpopulations warrant further investigation.

Asset Subtitle

Yuhchyau Chen

Meta Tag

Speaker Yuhchyau Chen

Topic Local-Regional NSCLC

Keywords

differential kinetics

blood and immune subpopulations

locally advanced lung cancer

treatment regimens

cisplatin-based chemoradiotherapy

low-dose radiosensitizing paclitaxel CRT

peripheral blood cells

flow cytometry

myelosuppression

T-cell subpopulations