2023 World Conference on Lung Cancer (Posters)-P1.28. EVs-miRNAs-Based Models in Predicting Radiosensitive Patients with Local Advanced-NSCLC Who Can Benefit from Adaptive Radiotherapy

P1.28. EVs-miRNAs-Based Models in Predicting Radiosensitive Patients with Local Advanced-NSCLC Who Can Benefit from Adaptive Radiotherapy - PDF(Abstract)

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Pdf Summary

This study aimed to establish extracellular vesicles-microRNA (EVs-miRNA)-based models to predict radiotherapy-sensitivity (RS) in locally advanced non-small cell lung cancer (LA-NSCLC) patients. The researchers analyzed the expression profile of EVs-miRNA in the plasma of 5 LA-NSCLC patients with different radiosensitivity before radiotherapy. They then validated the findings in a cohort of 28 LA-NSCLC patients receiving concurrent chemoradiotherapy. Logistic regression was used to establish the models based on the identified miRNAs. <br /><br />The results showed that there were no significant differences in clinical features between RS and radiotherapy-resistant (RR) patients. The reduction in target lesion diameters and volume was greater in RS patients compared to RR patients. The researchers identified 142 differentially-expressed EVs-miRNAs associated with radiosensitivity, and EVs-miR-657, -4514, and -4797 were confirmed in the validation cohort. EVs-miR-657 was significantly downregulated in RR patients, while EVs-miR-4514 and EVs-miR-4797 were upregulated in RR patients. Radiosensitive predictive models based on these miRNAs were established, with good accuracy in predicting RS patients. The target genes of these miRNAs were mainly involved in pathways related to radiosensitivity regulation.<br /><br />In conclusion, EVs-miRNAs-based models can effectively predict RS patients in LA-NSCLC who can benefit more from adaptive radiotherapy (ART). This study provides guidance for the application of ART in the clinic and supports further exploration of radiosensitizers.

Asset Subtitle

Haihua Yang

Meta Tag

Speaker Haihua Yang

Topic Local-Regional NSCLC

Keywords

EVs-miRNA

radiotherapy-sensitivity

locally advanced non-small cell lung cancer

differentially-expressed EVs-miRNAs

radiosensitivity

radiotherapy-resistant

radiosensitive predictive models

target genes

adaptive radiotherapy

ART