2023 World Conference on Lung Cancer (Posters)-P1.28. Recurrence Dynamics for Pathological N2 Non-small Cell Lung Cancer depending on the IASLC Residual Tumor Descriptor

P1.28. Recurrence Dynamics for Pathological N2 Non-small Cell Lung Cancer depending on the IASLC Residual Tumor Descriptor - PDF(Abstract)

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The study presented at the WCLC 2023 conference aimed to investigate the recurrence dynamics of patients with pathologic N2 non-small cell lung cancer (NSCLC) based on the residual tumor (R) descriptor proposed by the International Association for the Study of Lung Cancer (IASLC). The researchers analyzed medical records from a single center of patients with pathologic N2 NSCLC who underwent curative intent anatomical resection between 2004 and 2021.<br /><br />A total of 1373 patients were included in the study, classified as follows: 576 (42.0%) in R0, indicating complete resection; 286 (20.8%) in R(un), indicating uncertain resection; and 511 (37.2%) in R1/R2, indicating incomplete resection. The most common reason for classification as R(un) was positive lymph nodes, followed by insufficient lymph node evaluation.<br /><br />In the analysis, the researchers found that patients classified as R(un) and R1/R2 had higher hazard ratios for disease progression compared to those in the R0 group. The highest hazard rate for disease progression was observed at around 12 months, regardless of the IASLC R criteria, but the hazard rate was 1.3 times higher in the R(un) group compared to the R0 group.<br /><br />There were no statistical differences in locoregional recurrence and mixed type recurrence between R0 and R(un), but there was a statistically significant difference in distant recurrence pattern. Furthermore, when analyzing subcategories of N2 descriptors, significant differences were observed in distant recurrence patterns in N2a1 and N2a2 but not in N2b between R0 and R(un).<br /><br />The study concludes that the IASLC R criteria have prognostic relevance in patients with pathologic N2 NSCLC. The R(un) group is highly heterogeneous, and the involvement of the highest lymph node can potentially affect distant recurrence patterns. Overall, this research provides valuable insights into the recurrence dynamics of N2 NSCLC based on the IASLC R criteria.

Asset Subtitle

In Ha Kim

Meta Tag

Speaker In Ha Kim

Topic Local-Regional NSCLC

Keywords

WCLC 2023 conference

recurrence dynamics

pathologic N2 NSCLC

IASLC

medical records

curative intent resection

hazard ratios

disease progression

lymph node involvement

prognostic relevance