2023 World Conference on Lung Cancer (Posters)-P1.28. Recurrence Dynamics for Pathological N2 Non-small Cell Lung Cancer depending on the IASLC Residual Tumor Descriptor

P1.28. Recurrence Dynamics for Pathological N2 Non-small Cell Lung Cancer depending on the IASLC Residual Tumor Descriptor - PDF(Slides)

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This study analyzed the recurrence dynamics in patients with pathologic N2 non-small cell lung cancer (NSCLC) according to the International Association for the Study of Lung Cancer (IASLC) Residual Tumor Descriptor. The study found that the IASLC R classification, which determines the completeness of surgical resection, has prognostic relevance in patients with pathologic N2 NSCLC. The hazard for recurrence showed a peak around 12 months, and there was no significant difference in recurrence timing between different R descriptors. The study also found that there is a possibility that the involvement of the highest lymph node can affect distant recurrence patterns. <br /><br />The study included a total of 1373 patients with NSCLC who underwent surgical treatment. The staging work-up for diagnosis and clinical staging was based on imaging modalities such as chest computed tomography, positron emission tomography (PET-CT), and brain magnetic resonance imaging (MRI). Surgical treatment included the anatomical resection of pulmonary parenchyma and systematic mediastinal lymph node dissection. Adjuvant chemotherapy was recommended for all patients with pathologically confirmed N2 NSCLC, and targeted therapy was used as an additional treatment option in cases of recurrence after adjuvant treatment. <br /><br />The study found that the IASLC R classification was associated with recurrence-free survival, with patients classified as R0 having the best outcomes, followed by those classified as R(un), and those classified as R1/2 having the worst outcomes. Univariable and multivariable Cox proportional hazards analyses were performed to identify the prognostic factors for recurrence, and the study found that the IASLC R classification, histology, and pathologic stage were significant independent prognostic factors. <br /><br />In conclusion, the IASLC R classification has prognostic relevance in patients with pathologic N2 NSCLC. The study provides insights into the recurrence dynamics according to the IASLC R classification and suggests that more intensive surveillance of distant recurrence should be performed around 12 months after surgery in patients with pathologic N2 NSCLC.

Asset Subtitle

In Ha Kim

Meta Tag

Speaker In Ha Kim

Topic Local-Regional NSCLC

Keywords

recurrence dynamics

pathologic N2 non-small cell lung cancer

IASLC Residual Tumor Descriptor

prognostic relevance

surgical resection

recurrence timing

lymph node involvement

surgical treatment

adjuvant chemotherapy

targeted therapy