2023 World Conference on Lung Cancer (Posters)-P1.28. Treatment Strategies for Locally-advanced NSCLC with Invasive T4 Tumors: A SEER Analysis in the Era of Precision Medicine

P1.28. Treatment Strategies for Locally-advanced NSCLC with Invasive T4 Tumors: A SEER Analysis in the Era of Precision Medicine - PDF(Abstract)

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Pdf Summary

A retrospective cohort study analyzed data from the Surveillance, Epidemiology, and End Results database to evaluate the benefits of different treatment strategies for locally-advanced non-small cell lung cancer (NSCLC) with invasive T4 tumors. The study divided the data into three time periods based on the development of precision medicine. The results showed that the median overall survival (mOS) of patients significantly increased over time. Surgery-based treatment had the longest mOS at 30.0 months, followed by chemoradiation (16.0 months), chemotherapy alone (10.0 months), and radiation alone (6.0 months). Cox survival analysis favored surgery-based treatment in each time period, especially in the most recent era. Patients who were older than 65 years, male, had stage N2-3, and were diagnosed with squamous cell lung cancer had shorter overall survival. In the era of 2018-2019, patients receiving chemotherapy alone and male patients showed increased survival benefits. The study concludes that with the development of precision medicine, personalized treatment strategies optimized through multidisciplinary treatment have improved patient survival. Among patients with major structure invasion, a surgery-based strategy showed superior benefits when combined with peri-operation treatments.

Asset Subtitle

Min Wang

Meta Tag

Speaker Min Wang

Topic Local-Regional NSCLC

Keywords

retrospective cohort study

locally-advanced non-small cell lung cancer

invasive T4 tumors

precision medicine

overall survival

surgery-based treatment

chemoradiation

chemotherapy alone

radiation alone

Cox survival analysis