2023 World Conference on Lung Cancer (Posters)-P2.02. PROphylactic Pirfenidonefor Prevention of Radiation Induced Pneumonitis in Patients with Lung Cancer(PROPeR study)

P2.02. PROphylactic Pirfenidonefor Prevention of Radiation Induced Pneumonitis in Patients with Lung Cancer(PROPeR study) - PDF(Abstract)

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A study conducted at the Tata Memorial Hospital in Mumbai aimed to investigate the effect of prophylactic administration of Pirfenidone (PFD) in reducing radiation-induced pneumonitis in lung cancer patients undergoing radical radiation therapy (RT). PFD is an approved treatment for idiopathic pulmonary fibrosis and has shown benefits in managing radiation-induced fibrosis. The study involved 48 eligible patients who received PFD orally, starting one week before RT and continuing for the entire duration of RT and 10 weeks after completion. The primary objective was to assess the role of PFD in reducing the decline of pulmonary function tests (PFT) at 3- and 6-months post radiation compared to pre-RT values. The study also aimed to evaluate the evolution of radiological features of pneumonitis, progression-free survival, overall survival, and quality of life. Preliminary analysis showed that PFD was well-tolerated, with no drug-related acute side effects. Out of the 32 patients who completed the study as per protocol, nine had died due to disease progression. The average change in PFTs at 3-months post RT from baseline values showed a slight decrease in FVC, an increase in FEV1, FEV1/DLCO ratio, and a significant decrease in DLCOsb. The study concludes that PFD has the potential to reduce radiation-induced pneumonitis and further follow-up will establish its efficacy in preventing the worsening of PFT and radiological evidence of pneumonitis. The study is categorized as a clinical trial in progress under the track of Local-Regional Non-small Cell Lung Cancer.

Asset Subtitle

Naveen Mummudi

Meta Tag

Speaker Naveen Mummudi

Topic Local-Regional NSCLC: Toxicities of Multimodality Therapy

Keywords

Tata Memorial Hospital

Pirfenidone

radiation-induced pneumonitis

lung cancer

radiation therapy

pulmonary function tests

radiological features

progression-free survival

quality of life

clinical trial