2023 World Conference on Lung Cancer (Posters)-P2.05. Understanding Genomic and Social Determinants of Cancer Immunotherapy Outcome across Ancestry

P2.05. Understanding Genomic and Social Determinants of Cancer Immunotherapy Outcome across Ancestry - PDF(Slides)

Pdf Summary

The study focuses on tumor sequencing of African ancestry individuals with lung adenocarcinoma to identify clinically relevant alterations. Next-generation sequencing of a cancer gene panel is used to identify somatic alterations and infer genetic ancestry. The study uses real-world diagnostic testing data and ancestry inference to understand the differences in alterations based on ancestry. The results show that there are differences in clinically actionable mutations in lung cancer patients with African ancestry. Ancestry-environment interaction, specifically between African ancestry and smoking exposure, is associated with somatic TP53 mutations in lung adenocarcinoma. The study suggests that there may be ancestry-driven biases in biomarker detection and outcome prediction, as well as differences in access to testing and targeted therapy. The study speculates that germline and environmental modifiers may play a role in these differences and recommends further investigation. Overall, the study highlights the importance of considering ancestry in cancer research and the potential implications for personalized medicine and treatment strategies.

Asset Subtitle

Jian Carrot-Zhang

Meta Tag

Speaker Jian Carrot-Zhang

Topic Metastatic NSCLC: Immunotherapy - Biomarker

Keywords

tumor sequencing

African ancestry

lung adenocarcinoma

clinically relevant alterations

next-generation sequencing

somatic alterations

genetic ancestry

clinically actionable mutations

ancestry-environment interaction

smoking exposure