2023 World Conference on Lung Cancer (Posters)-P2.20. A Precision Medicine Approach by Performing Comprehensive Cancer Genome Profiling of Thymomas and Recurrent Thymomas

P2.20. A Precision Medicine Approach by Performing Comprehensive Cancer Genome Profiling of Thymomas and Recurrent Thymomas - PDF(Slides)

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A research study conducted in Rome, Italy, focused on exploring the molecular characteristics of thymomas, rare mediastinal tumors, and their recurrence. The aim of the study was to gain a better understanding of these tumors in order to improve diagnosis, prognosis, and personalized treatment options for affected patients.<br /><br />The study performed comprehensive cancer genome profiling on surgical specimens from 23 paired primary and recurrent thymomas. The analysis revealed molecular alterations in cell cycle control and DNA repair pathways in recurrent thymomas. Specifically, amplifications of genes involved in cell cycle control were found in 74% of the patients, while mutations in genes related to DNA repair were identified in 26% of cases.<br /><br />The study did not find any significant differences between clinical variables and gene mutations. However, the molecular findings suggest potential target therapies and active clinical trials for these patients. The researchers identified several clinical trials available for recurrent thymomas based on the specific genetic alterations observed in the study.<br /><br />The research concludes that a precision medicine approach, utilizing the molecular information obtained through comprehensive cancer genome profiling, holds promise for the management of recurrent/advanced thymic neoplasms. This approach could potentially lead to the development of personalized treatment plans or off-label treatments for patients with specific genetic variants.<br /><br />In summary, this study highlights the importance of understanding the molecular characteristics of thymomas and their recurrence in order to improve patient outcomes. The findings suggest that a precision medicine approach based on comprehensive cancer genome profiling could be beneficial in the management of these tumors.

Asset Subtitle

Jessica Evangelista

Meta Tag

Speaker Jessica Evangelista

Topic Thymic Malignancy

Keywords

Rome

thymomas

recurrence

diagnosis

prognosis

personalized treatment

cancer genome profiling

gene mutations

target therapies

precision medicine