2023 World Conference on Lung Cancer (Posters)-P2.20. Does Radical Thymectomy Influence the Neurological Outcome in Patients Aged over 65 with Thymoma and Myasthenia Gravis?

P2.20. Does Radical Thymectomy Influence the Neurological Outcome in Patients Aged over 65 with Thymoma and Myasthenia Gravis? - PDF(Abstract)

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In this study, the researchers investigated the neurological outcomes of patients over 65 with thymoma and myasthenia gravis (MG) who underwent radical thymectomy. The International Consensus Guidance for Management of MG recommends radical thymectomy for non-thymomatous, generalized MG patients under 65, but not for those over 65. However, the neurological outcomes in this older patient population are not well studied. <br /><br />The study included 66 patients over 65 who had thymoma associated with MG and underwent surgery for oncological reasons between 2000 and 2022. The researchers collected clinical, neurological, surgical, and pathological data for analysis. The main demographic, clinical, surgical, and neurological features of the patients were described. <br /><br />After surgery, radical thymectomy was found to be effective in controlling MG symptoms in a high percentage of cases (94%), with 8 patients experiencing a complete stable response. The researchers also found that the surgical approach and pre-operative Osserman score were associated with the neurological outcome. The patients treated by sternotomy and those with a lower Osserman score had a higher probability of achieving a complete neurological response. <br /><br />The findings suggest that radical thymectomy performed for oncological reasons in patients over 65 with thymoma and MG can be an effective treatment for improving neurological symptoms. However, further analysis is needed to determine the role of thymectomy in patients over 65 with MG but without thymoma.

Asset Subtitle

Filippo Lococo

Meta Tag

Speaker Filippo Lococo

Topic Thymic Malignancy

Keywords

neurological outcomes

patients over 65

thymoma

myasthenia gravis

radical thymectomy

clinical data

surgical data

pathological data

MG symptoms

neurological response