2023 World Conference on Lung Cancer (Posters)-P2.21. A Novel Proteomic Technique Uncovers New Diagnostic Biomarkers for Malignant Pleural Mesothelioma

P2.21. A Novel Proteomic Technique Uncovers New Diagnostic Biomarkers for Malignant Pleural Mesothelioma - PDF(Slides)

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Researchers have developed a novel proteomics technique to identify potential diagnostic biomarkers for pleural mesothelioma (PM), a type of cancer that affects the lining of the lungs. Currently, invasive diagnostic techniques contribute to a late diagnosis and poor prognosis for PM patients. Therefore, the search for less invasive alternatives, such as blood biomarkers, is crucial.<br /><br />The objective of this study was to identify new biomarker candidates that can differentiate PM patients from different control groups. The researchers analyzed intracellular proteins in plasma samples from PM patients, lung cancer patients, asymptomatic asbestos-exposed controls, and healthy controls. They used a combination of differential expression analysis and mass spectrometry to identify unique proteins.<br /><br />The researchers found that the number of identified intracellular proteins had a discriminatory capacity. Additionally, they identified a biomarker panel that could accurately distinguish PM patients from the control groups. However, further research and validation are necessary to confirm these findings.<br /><br />The study highlights the potential of using blood biomarkers, specifically tissue leakage proteins, as less invasive alternatives for the diagnosis of PM. The identified biomarker panel shows promise in differentiating PM patients from control groups with a high accuracy.<br /><br />In conclusion, this study presents a novel proteomics technique that has uncovered new diagnostic biomarker candidates for PM. These findings have the potential to improve the early detection and prognosis of PM, ultimately leading to better patient outcomes.

Asset Subtitle

Kevin Lamote

Meta Tag

Speaker Kevin Lamote

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

proteomics technique

diagnostic biomarkers

pleural mesothelioma

lung cancer

invasive diagnostic techniques

blood biomarkers

intracellular proteins

differential expression analysis

mass spectrometry

tissue leakage proteins