2023 World Conference on Lung Cancer (Posters)-P2.21. CD47 as Biomarker of Prognosis in Patients with Malignant Pleural Mesothelioma

P2.21. CD47 as Biomarker of Prognosis in Patients with Malignant Pleural Mesothelioma - PDF(Slides)

Pdf Summary

In this study, researchers investigated the role of CD47, a protein associated with immune evasion in cancer cells, in malignant pleural mesothelioma (MPM). They analyzed tumor biopsies from MPM patients and found that CD47 expression was observed in 49.2% of the patients. Lack of CD47 expression was associated with worse overall survival. This finding suggests that CD47 may serve as a biomarker for prognosis in MPM.<br /><br />The study also investigated the correlation between CD47 expression and immune infiltration. It was found that CD47 expression was positively correlated with B-cell infiltration and negatively correlated with CD4 T-cell infiltration. However, there was no correlation between CD47 expression and other immune cell types such as CD8 T-cells, macrophages, neutrophils, and dendritic cells.<br /><br />Additionally, the study explored the relationship between CD47 and other molecules. CD47 expression was found to be positively correlated with the expression of SIRPα, VEGFR2, and ubiquilin-1. The interaction of CD47 with VEGFR2 and ubiquilin-1 should be further investigated as they may play a role in potential therapeutic options.<br /><br />The study used bioinformatics analysis to confirm the results. They analyzed CD47 expression in an additional 85 MPM patients from the TCGA database and found a positive trend towards superior survival in patients with high CD47 expression.<br /><br />Overall, this study suggests that CD47 expression may have prognostic relevance in MPM. Further research is needed to understand the mechanisms of CD47 interaction and its potential as a therapeutic target in MPM.

Asset Subtitle

Oscar Arrieta

Meta Tag

Speaker Oscar Arrieta

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

CD47

immune evasion

malignant pleural mesothelioma

biomarker

prognosis

immune infiltration

B-cell infiltration

CD4 T-cell infiltration

therapeutic options

prognostic relevance