2023 World Conference on Lung Cancer (Posters)-P2.21. Characterization of the Genomic and Immune Landscape of Malignant Pleural Mesothelioma

P2.21. Characterization of the Genomic and Immune Landscape of Malignant Pleural Mesothelioma - PDF(Abstract)

Pdf Summary

This study aimed to characterize the genomic and immune landscape of malignant pleural mesothelioma (MPM) in the era of immunotherapy. The analysis included 22 patients with biopsy proven MPM. The patients were primarily diagnosed with epithelioid MPM, and most of them underwent multimodality treatment including radical surgery.<br /><br />The researchers utilized Imaging Mass Cytometry (IMC) to identify different cell phenotypes in the tumor samples. The main cell phenotypes identified were tumor cells, immune cells, stromal cells, and endothelial cells. The study found that patients with higher immune infiltrate had enhanced survival compared to those with lower immune infiltration, regardless of the specific immune cell population analyzed.<br /><br />From the genomic analysis, the researchers identified 671 somatic functional variants in the tumor samples, including mutations in the genes BAP1, NF2, MT-ND5, and TTN. The median tumor mutational burden (TMB) was 2.7, and a significant association was found between higher TMB and worse overall survival. Interestingly, increased immune infiltration correlated with a lower TMB and improved survival.<br /><br />In conclusion, the study suggests that increased immune infiltrate and low TMB are associated with better overall survival in MPM patients. This indicates that the quality, rather than the quantity, of mutations drives the anti-tumor immune response and is linked to a more favorable prognosis. These findings contribute to our understanding of MPM and may have implications for the development of immunotherapeutic strategies for this aggressive cancer.

Asset Subtitle

Andrea Bille

Meta Tag

Speaker Andrea Bille

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

malignant pleural mesothelioma

immunotherapy

Imaging Mass Cytometry

immune infiltrate

survival

somatic functional variants

tumor mutational burden

overall survival

anti-tumor immune response

immunotherapeutic strategies